SemenMar / SemenIgG / SemenIgA

Detection of anti-sperm-antibodies (ASA)

“Immunological Infertility” describes the absence of a conception as a result of disorders of the immune system on the reproductive organs. The majority of these disorders are due to the presence of anti-spermatozoa antibodies (ASA) that can occur in both sexes. Immunoglobulins (antibodies) are regarded as defense mechanisms of the body against foreign bodies or substances. When the body recognizes a “foreign” substance, it tries to build immunity against the substance by means of antibodies. In the case of sperm antibodies, however, the body recognizes the sperm as foreign, builds antibodies against it and thus affects the reproductive process. Antibodies formed by the defense system of the woman inhibit the sperm from passing through the cervical mucus and reaching the ovum. In men, antibodies to the spermatozoa may also be involved, making the passage of the sperm cells through the cervical mucus more difficult. Causes of the development of these antibodies are possibly infections and / or injury in the genital tract, or an autoimmune disease.
Sperm antibodies in ejaculate are almost always the IgA and / or IgG classes. Data indicate that IgA antibodies are clinically more significant than IgG antibodies, but rarely occur alone. ASA in the serum is predominantly IgG, in the case of ASA in the ejaculate or in the cervical mucus around IgA.

SemenMar
(mixed antiglobulin reaction test)

Ready-to-use

Indicates presence of IgG and/ or IgA-antibodies on motile sperm cells.

Detection with Anti-IgG and Anti-IgA-coated yellow microspheres

Shelf life is 18 months from time of manufacture if the product are stored at 2-8°C.

Part Number: ZR11100-MAR

SemenIgG

Ready-to-use

Indicates presence of immunglobulin G (IgG)-type antibodies on motile sperm cells.

Detection with Anti-IgG-coated blue microspheres

Shelf life is 18 months from time of manufacture if the product are storeb at 2-8°C.

Part Number: ZR11400-IgG

SemenIgA

Ready-to-use

Indicates presence of immunglobin A IgA-antibodies on motile sperm cells.

Detection witg Anti-IgA-coated red microspheres

Shelf life is 18 months from time of manufacture if the product are stored at 2-8°C.

Part Number: ZR11200-IgA

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